Johns Hopkins AI Professor Uses Machine Learning to Predict Sepsis

Suchi Saria, a 35-year-old professor at Johns Hopkins University and founder of AI startup Bayesian Health, is revolutionizing healthcare through artificial intelligence and machine learning. Featured on Business Insider’s 2024 AI Power List, Saria directs the machine learning and healthcare lab at Johns Hopkins while leading her company’s mission to make healthcare more efficient and predictive.

Saria’s journey into healthcare AI began during her doctorate at Stanford, coinciding with President Barack Obama’s signing of the Hitech Act to promote electronic health records. Her early work focused on developing algorithms to identify premature infants at high risk of deadly complications. However, the tragic loss of her nephew to sepsis became the catalyst for founding Bayesian Health, transforming her academic research into real-world hospital solutions.

Bayesian Health emerged from stealth in 2021 with $15 million in funding from Andreessen Horowitz and other investors. The startup’s flagship achievement is an AI algorithm that predicts sepsis faster than traditional methods, resulting in nearly 20% fewer sepsis-related deaths according to a groundbreaking study published in Nature Medicine in July 2022. Saria considers this research “probably my proudest achievement.”

The company has secured partnerships with major healthcare technology providers including Epic, Oracle’s Cerner, and Allscripts, while top health systems like Cleveland Clinic and Northwell Health have implemented its technology. While initially focused on sepsis prediction, Bayesian Health is expanding to forecast other medical complications including pressure ulcers and deep-vein thrombosis in pregnant patients. Saria envisions applications across “100 conditions” throughout healthcare.

Beyond her startup, Saria continues groundbreaking research at Johns Hopkins and has made angel investments in over 15 AI startups. The World Economic Forum recognized her contributions by naming her a Young Global Leader in 2018. In response to concerns about inadequate healthcare AI implementations—such as Epic’s sepsis algorithm that performed poorly according to a 2021 JAMA Internal Medicine study—Saria cofounded the Coalition for Health AI in 2022. This initiative brings together federal agencies and healthcare organizations to establish best practices for AI deployment. She also contributed to the National Academy of Medicine’s code of conduct for AI deployment, released earlier this year.

Key Quotes

We should not be practicing like we live in the 18th century with no science and no engineering. We should be up-leveling the way we deliver care to match the level of scientific innovation we see in the rest of our lives.

Saria articulated her vision for modernizing healthcare through AI and technology, emphasizing the disconnect between medical practice and the technological advances available in other industries. This statement captures her fundamental motivation for bringing machine learning to clinical settings.

I see 100 conditions where this system applies. It’s not just one or two — it’s everywhere I look.

Saria expressed the vast potential for her AI technology beyond sepsis prediction, indicating ambitious expansion plans for Bayesian Health. This quote reveals her vision for widespread application of predictive algorithms across numerous medical conditions and complications.

Our Take

Saria’s trajectory from academic researcher to successful AI entrepreneur represents an increasingly important pathway for translating AI innovation into real-world impact. Her personal motivation—losing her nephew to sepsis—adds a compelling human dimension to what could otherwise be purely technical work. The 20% reduction in sepsis deaths is particularly significant given that sepsis kills approximately 270,000 Americans annually, suggesting her technology could save tens of thousands of lives. Her proactive role in establishing AI governance through the Coalition for Health AI demonstrates mature leadership in addressing the industry’s credibility challenges, particularly following high-profile failures like Epic’s sepsis algorithm. As healthcare AI faces growing scrutiny over accuracy and bias, Saria’s commitment to rigorous validation and ethical deployment standards positions her as both innovator and responsible steward of the technology’s future in medicine.

Why This Matters

Saria’s work represents a critical intersection of artificial intelligence and healthcare at a time when the medical industry desperately needs technological innovation. Her success in reducing sepsis deaths by nearly 20% demonstrates AI’s potential to save lives at scale, addressing one of healthcare’s most deadly and costly complications. The partnerships with major electronic health record providers like Epic and Oracle’s Cerner signal mainstream adoption of predictive AI in clinical settings.

This story matters because it showcases how AI can move beyond theoretical research into practical, life-saving applications. Saria’s dual role as academic researcher and startup founder exemplifies the necessary bridge between university innovation and commercial healthcare deployment. Her leadership in establishing industry standards through the Coalition for Health AI addresses growing concerns about AI reliability and safety in medical settings. As healthcare systems worldwide struggle with efficiency and patient outcomes, Saria’s approach offers a scalable model for using machine learning to predict and prevent medical complications before they become critical, potentially transforming how hospitals deliver care.

For those interested in learning more about artificial intelligence, machine learning, and effective AI communication, here are some excellent resources:

Source: https://www.businessinsider.com/suchi-saria-bayesian-health-johns-hopkins-ai-power-list-2024